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Article

Manganese-dependent polioviruses caused by mutations within the viral polymerase.

Journal of virology - 1 May 2003

Crotty Shane, Gohara David, Gilligan Devin K, Karelsky Sveta, Cameron Craig E, Andino Raul

Abstract excerpt

Viral RNA-dependent RNA polymerases exhibit great sequence diversity. Only six core amino acids are conserved across all polymerases of positive-strand RNA viruses of eukaryotes. While exploring the function of one of these completely conserved residues, asparagine 297 in the prototypic poliovirus polymerase 3D(pol), we identified three viable mutants with noncanonical amino acids at this conserved position....

Topics

Amino Acid Sequence
HeLa Cells
Humans
Manganese
Models, Molecular
Molecular Sequence Data
Mutation
Poliovirus
RNA, Viral
RNA-Dependent RNA Polymerase
Transfection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virus Replication

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Identifiers

PMID: 12692240
DOI: 10.1128/jvi.77.9.5378-5388.2003
PMCID: PMC153957

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12692240-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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