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Molecular mechanism of divalent-metal-induced activation of NS3 helicase and insights into Zika virus inhibitor design

18 Oct 2016

Abstract excerpt

Zika virus has attracted increasing attention because of its potential for causing human neural disorders, including microcephaly in infants and Guillain–Barré syndrome. Its NS3 helicase domain plays critical roles in NTP-dependent RNA unwinding and translocation during viral replication. Our structural analysis revealed a pre-activation state of NS3 helicase in complex with GTPγS, in which the triphosphate...

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PMID: 27915293
DOI: 10.1093/nar/gkw941

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