Metal ions govern coronavirus endoribonuclease activity.

doi:10.1093/nar/gkaf1508

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Article

Metal ions govern coronavirus endoribonuclease activity.

Nucleic acids research - 14 Jan 2026

Wang Xionglue, Li Jing, Liu Zhichao, Wang Longfei, Zhu Bin

Abstract excerpt

Coronavirus nonstructural protein 15 (nsp15) is an endoribonuclease that restricts viral double-stranded RNA (dsRNA) accumulation in the cytosol to evade host immunity. Given the co-localization of nsp15 and replicating viral RNA, the mechanism controlling nsp15 activity is essential, yet poorly understood. Although metal ions are widely used as cofactors for enzymes, their role in nsp15 remains elusive. Here, we...

Topics

Cobalt
SARS-CoV-2
Zinc
Viral Nonstructural Proteins
Endoribonucleases
Nickel
Cryoelectron Microscopy
Catalytic Domain
RNA, Double-Stranded
Humans
Metals
RNA, Viral
Mutation
Protein Binding

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Identifiers

PMID: 41533565
DOI: 10.1093/nar/gkaf1508
PMCID: PMC12802955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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