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Article

Structural explanation for the role of Mn2+ in the activity of phi6 RNA-dependent RNA polymerase.

Nucleic acids research - 1 Nov 2008

Poranen Minna M, Salgado Paula S, Koivunen Minni R L, Wright Sam, Bamford Dennis H, Stuart David I, Grimes Jonathan M

Abstract excerpt

The biological role of manganese (Mn(2+)) has been a long-standing puzzle, since at low concentrations it activates several polymerases whilst at higher concentrations it inhibits. Viral RNA polymerases possess a common architecture, reminiscent of a closed right hand. The RNA-dependent RNA polymerase (RdRp) of bacteriophage 6 is one of the best understood examples of this important class of polymerases. We have...

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Identifiers

PMID: 18940872
DOI: 10.1093/nar/gkn632
PMCID: PMC2582606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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