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Article

Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase.

European journal of pharmacology - 14 Dec 2008

Gong Ying-Zi, Ding Wei-Guang, Wu Jie, Tsuji Keiko, Horie Minoru, Matsuura Hiroshi

Abstract excerpt

In humans, Kv1.5 (hKv1.5) channels conduct the ultra-rapid delayed rectifier K(+) current (I(Kur)) that is important for the repolarization of cardiac action potentials. We aimed at examining the effect of lipoxygenase inhibitors cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate (CDC), nordihydroguaiaretic acid (NDGA), and gossypol on hKv1.5 wild-type and mutant channels heterologously expressed in Chinese hamster...

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PMID: 18930721
DOI: 10.1016/j.ejphar.2008.10.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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