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Article

Hydroxyeicosatetraenoic acid oxidation in Chinese hamster ovary cells: a peroxisomal metabolic pathway.

Biochimica et biophysica acta - 20 Aug 1991

Gordon J A, Zoeller R A, Spector A A

Abstract excerpt

To evaluate the peroxisomal requirement for beta-oxidation of hydroxyeicosatetraenoic acids (HETES), we tested 5-, 12- and 15-HETE oxidation in wild-type and mutant Chinese hamster ovary (CHO) cells. Mutant CHO cells contain peroxisomal ghosts, have random cytosolic localization of catalase and lack two of the enzymes necessary for peroxisomal beta-oxidation. Reverse-phase HPLC indicated that 33% of 12-HETE...

Topics

Animals
Blotting, Western
Cells, Cultured
Chromatography, High Pressure Liquid
Citrate (si)-Synthase
Cricetinae
Cricetulus
Electrophoresis, Polyacrylamide Gel
Fatty Acids
Female
Hydroxyeicosatetraenoic Acids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microbodies

Mutation

Ovary

Oxidation-Reduction

Superoxide Dismutase

Source

Identifiers

PMID: 1892874
DOI: 10.1016/0005-2760(91)90227-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1892874-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Hydroxyeicosatetraenoic acid oxidation in Chinese hamster ovary cells: a peroxisomal metabolic pathway.PMID 1892874Read ↗

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