Article
Abnormal lipid metabolism in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia.
The Journal of biological chemistry - 17 Dec 2004
Namekata Kazuhiko, Enokido Yasushi, Ishii Isao, Nagai Yasuo, Harada Takayuki, Kimura Hideo
Abstract excerpt
Hyperhomocysteinemia (HHCY) is a consequence of impaired methionine/cysteine metabolism and is caused by deficiency of vitamins and/or enzymes such as cystathionine beta-synthase (CBS). Although HHCY is an important and independent risk factor for cardiovascular diseases that are commonly associated with hepatic steatosis, the mechanism by which homocysteine promotes the development of fatty liver is poorly...
Topics
- Animals
- Apolipoprotein B-100
- Apolipoproteins B
- Blotting, Northern
- Cholesterol
- Chromatography, High Pressure Liquid
- Cystathionine beta-Synthase
- Disease Models, Animal
- Electrophoresis, Agar Gel
- Electrophoresis, Polyacrylamide Gel
- Endothelium, Vascular
- Gene Expression Regulation