Alterations of fatty acid metabolism and membrane fluidity in peroxisome-defective mutant ZP102 cells.

doi:10.1007/s11745-004-1200-z

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Article

Alterations of fatty acid metabolism and membrane fluidity in peroxisome-defective mutant ZP102 cells.

Lipids - 1 Jan 2004

Nagura Michiaki, Saito Makiko, Iwamori Masao, Sakakihara Yoichi, Igarashi Takashi

Abstract excerpt

We investigated lipid composition and FA metabolism in Chinese hamster ovary CHO-K1) cells and Pex5-mutated CHO-K1 (ZP102) cells to clarify the biochemical bases of peroxisome biogenesis disorders (PBD). ZP102 cells have defective peroxisomes and exhibit impairments of peroxisomal beta-oxidation of FA and plasmalogen biosynthesis. In addition, we identified FA metabolic alterations in the synthesis of several...

Topics

Animals
CHO Cells
Carbon Isotopes
Cricetinae
Cricetulus
Fatty Acids
Lipid Metabolism
Membrane Fluidity
Mutation
Peroxisomes

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Identifiers

PMID: 15055234
DOI: 10.1007/s11745-004-1200-z

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