Article
Peroxisomal activation of long- and very long-chain fatty acids in the yeast Pichia pastoris.
Biochemical and biophysical research communications - 5 Jan 1995
Kalish J E, Chen C I, Gould S J, Watkins P A
Abstract excerpt
In mammals, beta-oxidation of very long-chain fatty acids (VLCFA) takes place in peroxisomes. This process is impaired in X-linked adrenoleukodystrophy (XALD) patients as a result of decreased activity of peroxisomal very long-chain acyl-CoA synthetase (VLCS). We investigated VLCFA and long chain fatty acid (LCFA) activation in the yeast Pichia pastoris. Both VLCFA and LCFA were activated to their CoA derivatives...
Topics
- Adrenoleukodystrophy
- Carbon-Sulfur Ligases
- Cell Fractionation
- Centrifugation, Density Gradient
- Coenzyme A Ligases
- Fatty Acids, Nonesterified
- Genes, Fungal
- Humans
- Ligases
- Microbodies
- Mutation