Article
Peroxisomal activation of long- and very long-chain fatty acids in the yeast Pichia pastoris.
Biochemical and biophysical research communications - 5 Jan 1995
Kalish J E, Chen C I, Gould S J, Watkins P A
Abstract excerpt
In mammals, beta-oxidation of very long-chain fatty acids (VLCFA) takes place in peroxisomes. This process is impaired in X-linked adrenoleukodystrophy (XALD) patients as a result of decreased activity of peroxisomal very long-chain acyl-CoA synthetase (VLCS). We investigated VLCFA and long chain fatty acid (LCFA) activation in the yeast Pichia pastoris. Both VLCFA and LCFA were activated to their CoA derivatives...
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