A rapid selection for animal cell mutants with defective peroxisomes.

doi:10.1016/0304-4165(90)90066-6

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Article

A rapid selection for animal cell mutants with defective peroxisomes.

Biochimica et biophysica acta - 16 May 1990

Morand O H, Allen L A, Zoeller R A, Raetz C R

Abstract excerpt

Chinese hamster ovary (CHO) cells take up and incorporate 9-(1'-pyrene)nonanol (P9OH) into phospholipids and neutral lipids. Exposure of P9OH-labeled cells to long wavelength ultraviolet (UV) light causes cell death, because excitation of the pyrene moiety generates reactive oxygen species. CHO mutant cells deficient in plasmalogen biosynthesis and peroxisome assembly (Zoeller, R.A. and Raetz, C.R.H. (1986) Proc....

Topics

Animals
Catalase
Cell Line
Cell Survival
Cholesterol
Cricetinae
Cytosol
Fatty Alcohols
Female
Flow Cytometry
Free Radicals
Microbodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Ovary

Oxygen

Phospholipids

Photochemistry

Plasmalogens

Source

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Identifiers

PMID: 2354189
DOI: 10.1016/0304-4165(90)90066-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2354189-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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