IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells.

doi:10.1093/hmg/ddn342

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Article

IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells.

Human molecular genetics - 15 Jan 2009

Liu Siyang, Wang Hongjie, Jin Yulan, Podolsky Robert, Reddy M V Prasad Linga, Pedersen Jennifer, Bode Bruce, Reed John, Steed Dennis, Anderson Steve, Yang Ping, Muir Andy, Steed Leigh, Hopkins Diane, Huang Yihua, Purohit Sharad, Wang Cong-Yi, Steck Andrea K, Montemari Annalisa, Eisenbarth George, Rewers Marian, She Jin-Xiong

Abstract excerpt

Genome-wide association (GWA) studies revealed a number of single nucleotide polymorphisms (SNPs) significantly associated with type 1 diabetes (T1D). In an attempt to confirm some of these candidate associations, we genotyped 2046 Caucasian patients and 2417 normal controls from the United States for SNPs in five genomic regions. While no evidence was obtained for four genomic regions (rs2929366/NM_144715 on...

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PMID: 18927125
DOI: 10.1093/hmg/ddn342
PMCID: PMC2638779

Genes

IFIH1
CAPSL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells.PMID 18927125Read ↗

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The Type 1 Diabetes-Associated Single Nucleotide Polymorphism rs1990760 in IFIH1 Is Associated with Increased Basal Type I IFNs and IFN-stimulated Gene Expression.Semantic proximity Read ↗

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A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.Semantic proximity Read ↗

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