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Article

The association between the IFIH1 locus and type 1 diabetes.

Diabetologia - 1 Mar 2008

Qu H-Q, Marchand L, Grabs R, Polychronakos C

Abstract excerpt

AIMS/HYPOTHESIS: We set out to validate a recently reported type 1 diabetes association from the IFIH1 gene variation in an independent cohort from a population of mixed European descent. METHODS: We genotyped five single-nucleotide polymorphisms in the IFIH1 locus, i.e. rs2111485, rs1990760, rs3...

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Source

Identifiers

PMID: 18071670
DOI: 10.1007/s00125-007-0895-6

Genes

IFIH1
FAP
GCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18071670-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The association between the IFIH1 locus and type 1 diabetes.PMID 18071670Read ↗

IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells.Semantic proximity Read ↗

Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.Semantic proximity Read ↗

Cumulative effect of IFIH1 variants and increased gene expression associated with type 1 diabetes.Semantic proximity Read ↗

IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in Chinese Han population.Semantic proximity Read ↗

The interferon-induced helicase IFIH1 Ala946Thr polymorphism is associated with type 1 diabetes in both the high-incidence Finnish and the medium-incidence Hungarian populations.Semantic proximity Read ↗

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.Semantic proximity Read ↗

The IFIH1-A946T risk variant promotes diabetes in a sex-dependent manner.Semantic proximity Read ↗

Effects of type 1 diabetes-associated IFIH1 polymorphisms on MDA5 function and expression.Semantic proximity Read ↗

The IFIH1-A946T risk variant promotes diabetes in a sex-dependent mannerSemantic proximity Read ↗

Reduced expression of IFIH1 is protective for type 1 diabetes.Semantic proximity Read ↗

Population genetics of IFIH1: ancient population structure, local selection, and implications for susceptibility to type 1 diabetes.Semantic proximity Read ↗

An interferon-induced helicase (IFIH1) gene polymorphism associates with different rates of progression from autoimmunity to type 1 diabetes.Semantic proximity Read ↗

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