Article
Serotonin transporter gene variation and stressful life events impact processing of fear and anxiety.
The international journal of neuropsychopharmacology - 1 Apr 2009
Armbruster Diana, Moser Dirk Alexander, Strobel Alexander, Hensch Tilman, Kirschbaum Clemens, Lesch Klaus-Peter, Brocke Burkhard
Abstract excerpt
Genetic variation of the serotonin transporter (5-HTT) has been associated with fear- and anxiety-related behaviours. The amygdala is considered crucial in emotional modulation and stronger amygdala reactivity in response to fearful stimuli has been found in carriers of the short (S) allele of the 5-HTT gene in imaging studies. Additionally, reactivity of amygdala-innervated effectory systems is also of...
Topics
- Acoustic Stimulation
- Adult
- Analysis of Variance
- Anxiety
- Chi-Square Distribution
- Fear
- Female
- Genetic Variation
- Genotype
- Habituation, Psychophysiologic
- Humans