Serotonin transporter genetic variation and the response of the human amygdala.

doi:10.1126/science.1071829

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Article

Serotonin transporter genetic variation and the response of the human amygdala.

Science (New York, N.Y.) - 19 Jul 2002

Hariri Ahmad R, Mattay Venkata S, Tessitore Alessandro, Kolachana Bhaskar, Fera Francesco, Goldman David, Egan Michael F, Weinberger Daniel R

Abstract excerpt

A functional polymorphism in the promoter region of the human serotonin transporter gene (SLC6A4) has been associated with several dimensions of neuroticism and psychopathology, especially anxiety traits, but the predictive value of this genotype against these complex behaviors has been inconsistent. Serotonin [5- hydroxytryptamine, (5-HT)] function influences normal fear as well as pathological anxiety,...

Topics

Adult
Alleles
Amygdala
Carrier Proteins
Cohort Studies
Facial Expression
Fear
Female
Functional Laterality
Genetic Variation
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Magnetic Resonance Imaging

Male

Membrane Glycoproteins

Membrane Transport Proteins

Nerve Tissue Proteins

Personality

Source

Open in PubMed

Identifiers

PMID: 12130784
DOI: 10.1126/science.1071829

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12130784-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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