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Article

Influence of functional tryptophan hydroxylase 2 gene variation and sex on the startle response in children, young adults, and older adults.

Biological psychology - 1 Mar 2010

Armbruster Diana, Mueller Anett, Strobel Alexander, Kirschbaum Clemens, Lesch Klaus-Peter, Brocke Burkhard

Abstract excerpt

Serotonin, a key regulator of emotional behavior, is synthesized by tryptophan hydroxylase (TPH). Allelic variation of TPH2 gene expression influences serotonin synthesis in the brain and therefore may modulate emotional processing. Here, we investigated the influence of the -703 G/T polymorphism in the regulatory promoter region of the TPH2 gene on the startle response in three different age samples: children...

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Source

Identifiers

PMID: 20064585
DOI: 10.1016/j.biopsycho.2009.12.010

Genes

TPH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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