Article
Murine inter-strain polymorphisms alter gene targeting frequencies at the mu opioid receptor locus in embryonic stem cells.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Oct 2001
Zhou L, Rowley D L, Mi Q S, Sefcovic N, Matthes H W, Kieffer B L, Donovan D M
Abstract excerpt
Chromosomal regions near the mu opioid receptor gene are implicated in morphine preference by quantitative trait loci studies. Differences in expression of the mu opioid receptor are expected to contribute to differences in inter-individual (humans) or strain-specific (mice) responses to painful stimuli, opiate drugs, and addictive behaviors. The search for relevant genetic elements is hindered by a lack of...
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