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Article

Experimental investigation of the seesaw mechanism of the relay region that moves the myosin lever arm.

The Journal of biological chemistry - 5 Dec 2008

Kintses Bálint, Yang Zhenhui, Málnási-Csizmadia András

Abstract excerpt

A seesaw-like movement of the relay region upon the recovery step of myosin was recently simulated in silico. In this model the relay helix tilts around its pivoting point formed by a phenylalanine cluster (Phe(481), Phe(482), and Phe(652)), which moves the lever arm of myosin. To study the effect of the elimination of the proposed pivoting point, these phenylalanines were mutated to alanines in two Dictyostelium...

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Identifiers

PMID: 18854311
DOI: 10.1074/jbc.M805848200
PMCID: PMC2662230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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