Article
Toward understanding actin activation of myosin ATPase: the role of myosin surface loops.
Proceedings of the National Academy of Sciences of the United States of America - 18 Apr 2006
Onishi Hirofumi, Mikhailenko Sergey V, Morales Manuel F
Abstract excerpt
To understand the complicated interplay when a traveling myosin head reaches interaction distance with two actins in a filament we looked to three myosin loops that early on exert their influences from the "outside" of the myosin. On these we conduct, functionally test, and interpret strategically chosen mutations at sites thought from crystallography to be a patch for binding the "first" of the two actins. One...
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