Article
Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon.
Proceedings of the National Academy of Sciences of the United States of America - 7 Oct 2008
Kucherlapati Melanie H, Yang Kan, Fan Kunhua, Kuraguchi Mari, Sonkin Dmitriy, Rosulek Andrew, Lipkin Martin, Bronson Roderick T, Aronow Bruce J, Kucherlapati Raju
Abstract excerpt
To examine the role of Rb1 in gastrointestinal (GI) tumors, we generated mice with an Apc(1638N) allele, Rb(tm2brn) floxed alleles, and a villin-cre transgene (RBVCA). These animals had exon 19 deleted from Rb1 throughout the GI tract. We have shown previously that Rb1 deficiency is insufficient for GI tumor initiation, with inactivation of an Apc allele capable of overcoming the insufficiency. In this study we...
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