Article
BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3.
Gastroenterology - 1 Dec 2017
Liu Xicheng, Wei Wendi, Li Xiaowei, Shen Pengcheng, Ju Dapeng, Wang Zhen, Zhang Rukui, Yang Fu, Chen Chunyan, Cao Kun, Zhu Guoli, Chen Hongyan, Chen Liang, Sui Jianhua, Zhang Erquan, Wu Kaichun, Wang Fengchao, Zhao Liping, Xi Rongwen
Abstract excerpt
BACKGROUND & AIMS: Polycomb group proteins are epigenetic factors that silence gene expression; they are dysregulated in cancer cells and contribute to carcinogenesis by unclear mechanisms. We investigated whether BMI1 proto-oncogene, polycomb ring finger (BMI1), and polycomb group ring finger 2 (PCGF2, also called MEL18) are involved in the initiation and progression of colitis-associated cancer (CAC) in mice....
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