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Article

Runx1 is a tumor suppressor gene in the mouse gastrointestinal tract

16 Dec 2011

Abstract excerpt

The Runx1 transcription factor plays an important role in tissue homeostasis through its effects on stem/progenitor cell populations and differentiation. The effect of Runx1 on epithelial differentiation of the secretory cell lineage of the colon was recently demonstrated. This study aimed to examine the role of Runx1 in tumor development in epithelial cells of the gastrointestinal tract. Conditional knockout...

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PMID: 22171576
DOI: 10.1111/j.1349-7006.2011.02189.x

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