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Article

Inactivation of the retinoblastoma gene yields a mouse model of malignant colorectal cancer.

Oncogene - 26 Nov 2015

Parisi T, Bronson R T, Lees J A

Abstract excerpt

The retinoblastoma gene (Rb) is mutated at significant frequency in various human epithelial tumors, including colorectal cancer, and is strongly associated with metastatic disease. However, sole inactivation of Rb in the mouse has so far failed to yield epithelial cancers. Here, we specifically inactivate Rb and/or p53 in the urogenital epithelium and the intestine. We find that the loss of both tumor...

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Identifiers

PMID: 25745996
DOI: 10.1038/onc.2015.30
PMCID: PMC4668801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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