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Article

Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jun 2004

Haigis Kevin M, Hoff Peter D, White Alanna, Shoemaker Alex R, Halberg Richard B, Dove William F

Abstract excerpt

Inherited colorectal cancer syndromes in humans exhibit regional specificity for tumor formation. By using mice with germline mutations in the adenomatous polyposis coli gene (Apc) and/or DNA mismatch repair genes, we have analyzed the genetic control of tumor regionality in the mouse small intes...

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Identifiers

PMID: 15210940
DOI: 10.1073/pnas.0403338101
PMCID: PMC470749

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15210940-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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