Article
PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation.
Cancer research - 1 Oct 2008
Oda Katsutoshi, Okada Jennifer, Timmerman Luika, Rodriguez-Viciana Pablo, Stokoe David, Shoji Keiko, Taketani Yuji, Kuramoto Hiroyuki, Knight Zachary A, Shokat Kevan M, McCormick Frank
Abstract excerpt
Mutations in genes functioning in different pathways frequently occur together in the same cancer, whereas mutations in the same pathway tend to be mutually exclusive. However, the majority of colon, breast, and endometrial cancers that possess mutations in PIK3CA, the catalytic subunit p110alpha of phosphatidylinositol 3'-kinase (PI3K), also possess mutations or alterations in genes upstream of PI3K such as Ras,...
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