Article
PTEN-deficient cancers depend on PIK3CB.
Proceedings of the National Academy of Sciences of the United States of America - 2 Sept 2008
Wee Susan, Wiederschain Dmitri, Maira Sauveur-Michel, Loo Alice, Miller Christine, deBeaumont Rosalie, Stegmeier Frank, Yao Yung-Mae, Lengauer Christoph
Abstract excerpt
Deregulation of the PI3K signaling pathway is observed in many human cancers and occurs most frequently through loss of PTEN phosphatase tumor suppressor function or through somatic activating mutations in the Class IA PI3K, PIK3CA. Tumors harboring activated p110alpha, the protein product of PIK3CA, require p110alpha activity for growth and survival and hence are expected to be responsive to inhibitors of its...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.