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Article

PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma.

Cancer research - 1 Apr 2005

Saal Lao H, Holm Karolina, Maurer Matthew, Memeo Lorenzo, Su Tao, Wang Xiaomei, Yu Jennifer S, Malmström Per-Olof, Mansukhani Mahesh, Enoksson Jens, Hibshoosh Hanina, Borg Ake, Parsons Ramon

Abstract excerpt

Deregulation of the phosphatidylinositol 3-kinase (PI3K) pathway either through loss of PTEN or mutation of the catalytic subunit alpha of PI3K (PIK3CA) occurs frequently in human cancer. We identified PIK3CA mutations in 26% of 342 human breast tumor samples and cell lines at about equal frequency in tumor stages I to IV. To investigate the relationship between PTEN and PIK3CA, we generated a cohort of tumors...

Read the complete abstract on PubMed

Topics

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Share to Class I Phosphatidylinositol 3-Kinases
Share to Estrogen Receptor alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphatic Metastasis

Share to Phosphatidylinositol 3-Kinases

Share to Phosphoric Monoester Hydrolases

Share to PTEN Phosphohydrolase

Share to Receptor, ErbB-2

Share to Receptors, Progesterone

Source

Identifiers

PMID: 15805248
DOI: 10.1158/0008-5472-CAN-04-3913

Genes

PTEN
ERBB2
PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma.PMID 15805248Read ↗

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