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Article

The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells.

Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2005

Zhao Jean J, Liu Zhenning, Wang Li, Shin Eyoung, Loda Massimo F, Roberts Thomas M

Abstract excerpt

The PIK3CA gene encoding the p110alpha subunit of Class IA phosphatidylinositol 3-kinases (PI3Ks) is frequently mutated in human tumors. Mutations in the PIK3CB gene encoding p110beta, the only other widely expressed Class IA PI3K, have not been reported. We compared the biochemical activity and transforming potential of mutant forms of p110alpha and p110beta in a human mammary epithelial cell system. The two...

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Identifiers

PMID: 16339315
DOI: 10.1073/pnas.0508988102
PMCID: PMC1317954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells.PMID 16339315Read ↗

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