Genetic Polymorphisms in the Apoptosis-Associated Gene CASP3 and the Risk of Lung Cancer in Chinese Population.

doi:10.1371/journal.pone.0164358

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Genetic Polymorphisms in the Apoptosis-Associated Gene CASP3 and the Risk of Lung Cancer in Chinese Population.

PloS one - 1 Jan 2016

Lin Jia, Zhang Yanyan, Wang Hongge, Chang Jiang, Wei Lixuan, Cao Lei, Zhang Zhi, Zhang Xuemei

Abstract excerpt

Caspase-3 (CASP3) plays a central role in executing cell apoptosis and thus in carcinogenesis. We previously investigated the relationship between functional polymorphisms in CAPS3 829 A>C and 20541 C>T and risk of esophageal squamous cell carcinoma. However little is known about the role of CASP3 variants in susceptibility to lung cancer. To figure out the contribution of CASP3 polymorphisms to lung cancer risk,...

Topics

A549 Cells
Aged
Caspase 3
China
Female
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Genotype
Humans
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Neoplasm Proteins

Polymorphism, Restriction Fragment Length

Risk Factors

Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 27723786
DOI: 10.1371/journal.pone.0164358
PMCID: PMC5056705

Genes

CASP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Polymorphisms in the Apoptosis-Associated Gene CASP3 and the Risk of Lung Cancer in Chinese Population.PMID 27723786Read ↗

Identification of polymorphisms in the Caspase-3 gene and their association with lung cancer risk.Semantic proximity Read ↗

Genetic variant in CASP3 affects promoter activity and risk of esophageal squamous cell carcinoma.Semantic proximity Read ↗

Caspase 9 promoter polymorphisms and risk of primary lung cancer.Semantic proximity Read ↗

Polymorphisms in the caspase genes and the risk of lung cancer.Semantic proximity Read ↗

A literature-based systematic HuGE review and meta-analysis show that CASP gene family polymorphisms are associated with risk of lung cancer.Semantic proximity Read ↗

Involvement of CASP3 promoter polymorphism (-1337 C > G) in the development and progression of non-small cell lung cancer.Semantic proximity Read ↗

CASP 3 genetic polymorphisms and risk of Hepatocellular carcinoma: a case-control study in a Chinese population.Semantic proximity Read ↗

HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk.Semantic proximity Read ↗

Caspase8 rs1035142 G>T polymorphism was associated with an increased risk of esophageal cancer in a Chinese population.Semantic proximity Read ↗

Polymorphisms in the Caspase7 gene and the risk of lung cancer.Semantic proximity Read ↗

Association between CASP-8 gene polymorphisms and cancer risk in some Asian population based on a HuGE review and meta-analysis.Semantic proximity Read ↗

Association of CASP8 polymorphisms and cancer susceptibility: A meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.