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Article

Systems based mapping demonstrates that recovery from alkylation damage requires DNA repair, RNA processing, and translation associated networks.

Genomics - 1 Jan 2009

Rooney John P, George Ajish D, Patil Ashish, Begley Ulrike, Bessette Erin, Zappala Maria R, Huang Xin, Conklin Douglas S, Cunningham Richard P, Begley Thomas J

Abstract excerpt

The identification of cellular responses to damage can promote mechanistic insight into stress signalling. We have screened a library of 3968 Escherichia coli gene-deletion mutants to identify 99 gene products that modulate the toxicity of the alkylating agent methyl methanesulfonate (MMS). We have developed an ontology mapping approach to identify functional categories over-represented with MMS-toxicity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18824089
DOI: 10.1016/j.ygeno.2008.09.001
PMCID: PMC2633870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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