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Profiling the compendium of changes in Saccharomyces cerevisiae due to mutations that alter availability of the main methyl donor S-Adenosylmethionine.

G3 (Bethesda, Md.) - 3 Apr 2024

Remines McKayla, Schoonover Makailyn G, Knox Zoey, Kenwright Kailee, Hoffert Kellyn M, Coric Amila, Mead James, Ampfer Joseph, Seye Serigne, Strome Erin D

Abstract excerpt

The SAM1 and SAM2 genes encode for S-Adenosylmethionine (AdoMet) synthetase enzymes, with AdoMet serving as the main cellular methyl donor. We have previously shown that independent deletion of these genes alters chromosome stability and AdoMet concentrations in opposite ways in Saccharomyces cerevisiae. To characterize other changes occurring in these mutants, we grew wildtype, sam1Δ/sam1Δ, and sam2Δ/sam2Δ...

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Identifiers

PMID: 38184845
DOI: 10.1093/g3journal/jkae002
PMCID: PMC10989883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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