Article
The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British Caucasian patients.
Arthritis and rheumatism - 1 Oct 2008
Chinoy H, Platt H, Lamb J A, Betteridge Z, Gunawardena H, Fertig N, Varsani H, Davidson J, Oddis C V, McHugh N J, Wedderburn L R, Ollier W E R, Cooper R G
Abstract excerpt
OBJECTIVE: To examine single-nucleotide polymorphisms (SNPs) of the protein tyrosine phosphatase N22 gene (PTPN22) and to study the relationship between PTPN22 and the HLA region in patients with idiopathic inflammatory myopathies (IIMs). METHODS: PTPN22 SNPs were assessed in a large, cross-sectional, case-control study from the UK involving patients with adult or juvenile IIM, comprising patients with...
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