Article
An update on the immunogenetics of idiopathic inflammatory myopathies: major histocompatibility complex and beyond.
Current opinion in rheumatology - 1 Nov 2009
Chinoy Hector, Lamb Janine A, Ollier William E R, Cooper Robert G
Abstract excerpt
PURPOSE OF REVIEW: To update the reader on immunogenetic advances in idiopathic inflammatory myopathy (IIM) over the past 18 months. RECENT FINDINGS: In Caucasian IIM, despite a shared association with the human leukocyte antigen (HLA) 8.1 ancestral haplotype (HLA-DRB1*03-DQA1*05-DQB1*02), anti-Jo-1 and anti-PM-Scl antibody-positive cases have differing IIM clinical phenotypes. A study of the HLA-DPB1 region has...
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