Article
Aftiphilin and gamma-synergin are required for secretagogue sensitivity of Weibel-Palade bodies in endothelial cells.
Molecular biology of the cell - 1 Dec 2008
Lui-Roberts Winnie W Y, Ferraro Francesco, Nightingale Thomas D, Cutler Daniel F
Abstract excerpt
Formation of secretory organelles requires the coupling of cargo selection to targeting into the correct exocytic pathway. Although the assembly of regulated secretory granules is driven in part by selective aggregation and retention of content, we recently reported that adaptor protein-1 (AP-1) recruitment of clathrin is essential to the initial formation of Weibel-Palade bodies (WPBs) at the trans-Golgi...
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