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Article

The ALS- and FTD-associated proteins annexin A11 and CHMP2B act sequentially in plasma membrane repair.

Developmental cell - 8 Jul 2026

Heffner Catherine M, Starling Georgina P, Straker Lorian C, Hawes Philippa C, Isaacs Adrian M, Carlton Jeremy G

Abstract excerpt

Maintenance of plasma membrane integrity is essential for compartmentalization of the cytosol and for cellular viability. Upon membrane damage, several factors including endosomal sorting complex required for transport-III (ESCRT-III) proteins, annexins, stress granules, lipids, and membrane fusion proteins are mobilized to orchestrate membrane repair. However, whether these factors operate independently or act...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42349418
DOI: 10.1016/j.devcel.2026.05.014
PMCID: PMC13374510

Genes

CHMP2B
ANXA11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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