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Article

GGA function is required for maturation of neuroendocrine secretory granules.

The EMBO journal - 19 Apr 2006

Kakhlon Or, Sakya Prabhat, Larijani Banafshe, Watson Rose, Tooze Sharon A

Abstract excerpt

Secretory granule (SG) maturation has been proposed to involve formation of clathrin-coated vesicles (CCVs) from immature SGs (ISGs). We tested the effect of inhibiting CCV budding by using the clathrin adaptor GGA (Golgi-associated, gamma-ear-containing, ADP-ribosylation factor-binding protein) on SG maturation in neuroendocrine cells. Overexpression of a truncated, GFP-tagged GGA, VHS (Vps27, Hrs, Stam)-GAT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16601685
DOI: 10.1038/sj.emboj.7601067
PMCID: PMC1440831

Genes

GGA1
VAMP4
GGA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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