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Article

Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation.

The Journal of clinical investigation - 1 Feb 2005

Kasai Kazuo, Ohara-Imaizumi Mica, Takahashi Noriko, Mizutani Shin, Zhao Shengli, Kikuta Toshiteru, Kasai Haruo, Nagamatsu Shinya, Gomi Hiroshi, Izumi Tetsuro

Abstract excerpt

The monomeric small GTPase Rab27a is specifically localized on both secretory granules and lysosome-related organelles. Although natural mutations of the Rab27a gene in human Griscelli syndrome and in ashen mice cause partial albinism and immunodeficiency reflecting the dysfunction of lysosome-related organelles, phenotypes resulting from the defective exocytosis of secretory granules have not been reported. To...

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Identifiers

PMID: 15690086
DOI: 10.1172/JCI22955
PMCID: PMC546426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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