Article
Physiological roles of clathrin adaptor AP complexes: lessons from mutant animals.
Journal of biochemistry - 1 Jun 2006
Ohno Hiroshi
Abstract excerpt
Clathrin-associated adaptor protein (AP) complexes play a key role in the transport of proteins, by regulating the formation of transport vesicles as well as cargo selection, between organelles of the post-Golgi network, namely, the trans-Golgi network (TGN), endosomes, lysosomes and the plasma membrane. Evidence has been accumulating for the physiological importance of AP complexes. Deficiency in AP-1A or AP-2...
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