Physiological roles of clathrin adaptor AP complexes: lessons from mutant animals.

doi:10.1093/jb/mvj120

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Article

Physiological roles of clathrin adaptor AP complexes: lessons from mutant animals.

Journal of biochemistry - 1 Jun 2006

Ohno Hiroshi

Abstract excerpt

Clathrin-associated adaptor protein (AP) complexes play a key role in the transport of proteins, by regulating the formation of transport vesicles as well as cargo selection, between organelles of the post-Golgi network, namely, the trans-Golgi network (TGN), endosomes, lysosomes and the plasma membrane. Evidence has been accumulating for the physiological importance of AP complexes. Deficiency in AP-1A or AP-2...

Topics

Adaptor Proteins, Vesicular Transport
Animals
Clathrin
Epilepsy
Hermanski-Pudlak Syndrome
Humans
Mice
Models, Biological
Mutation
Transport Vesicles
trans-Golgi Network

Source

Open in PubMed

Identifiers

PMID: 16788044
DOI: 10.1093/jb/mvj120

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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