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Article

ORAI channels are critical for receptor-mediated endocytosis of albumin.

Nature communications - 4 Dec 2017

Zeng Bo, Chen Gui-Lan, Garcia-Vaz Eliana, Bhandari Sunil, Daskoulidou Nikoleta, Berglund Lisa M, Jiang Hongni, Hallett Thomas, Zhou Lu-Ping, Huang Li, Xu Zi-Hao, Nair Viji, Nelson Robert G, Ju Wenjun, Kretzler Matthias, Atkin Stephen L, Gomez Maria F, Xu Shang-Zhong

Abstract excerpt

Impaired albumin reabsorption by proximal tubular epithelial cells (PTECs) has been highlighted in diabetic nephropathy (DN), but little is known about the underlying molecular mechanisms. Here we find that ORAI1-3, are preferentially expressed in PTECs and downregulated in patients with DN. Hyperglycemia or blockade of insulin signaling reduces the expression of ORAI1-3. Inhibition of ORAI channels by BTP2 and...

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Source

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Identifiers

PMID: 29203863
DOI: 10.1038/s41467-017-02094-y
PMCID: PMC5714946

Genes

ORAI1
AMN
STIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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