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Article

An essential role for Grk2 in Hedgehog signalling downstream of Smoothened.

EMBO reports - 1 May 2016

Zhao Zhonghua, Lee Raymond Teck Ho, Pusapati Ganesh V, Iyu Audrey, Rohatgi Rajat, Ingham Philip W

Abstract excerpt

The G-protein-coupled receptor kinase 2 (adrbk2/GRK2) has been implicated in vertebrate Hedgehog (Hh) signalling based on the effects of its transient knock-down in mammalian cells and zebrafish embryos. Here, we show that the response to Hh signalling is effectively abolished in the absence of Grk2 activity. Zebrafish embryos lacking all Grk2 activity are refractory to both Sonic hedgehog (Shh) and oncogenic...

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Source

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Identifiers

PMID: 27113758
DOI: 10.15252/embr.201541532
PMCID: PMC5341524

Genes

GRK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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An essential role for Grk2 in Hedgehog signalling downstream of Smoothened.PMID 27113758Read ↗

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