Article
Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway.
Science (New York, N.Y.) - 24 Dec 2004
Wilbanks Alyson M, Fralish Gregory B, Kirby Margaret L, Barak Larry S, Li Yin-Xiong, Caron Marc G
Abstract excerpt
beta-arrestins are multifunctional proteins that act as scaffolds and transducers of intracellular signals from heptahelical transmembrane-spanning receptors (7TMR). Hedgehog (Hh) signaling, which uses the putative 7TMR, Smoothened, is established as a fundamental pathway in development, and unregulated Hh signaling is associated with certain malignancies. Here, we show that the functional knockdown of...
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