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Article

Zag expression during aging suppresses proliferation after kidney injury.

Journal of the American Society of Nephrology : JASN - 1 Dec 2008

Schmitt Roland, Marlier Arnaud, Cantley Lloyd G

Abstract excerpt

Recovery after acute kidney injury is impaired in the elderly, but mechanistic information regarding why this occurs is limited. In this study, aged mouse kidneys displayed a reduced epithelial proliferative reserve in vivo and in vitro. Microarray analysis identified increased expression of zinc-alpha (2)-glycoprotein (Zag) in aged proximal tubular cells. The addition of recombinant Zag to primary renal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18815245
DOI: 10.1681/ASN.2008010035
PMCID: PMC2588107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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