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Zinc-α2-Glycoprotein Exerts Antifibrotic Effects in Kidney and Heart

18 Mar 2015

Abstract excerpt

Zinc-α2-glycoprotein (AZGP1) is a secreted protein synthesized by epithelial cells and adipocytes that has roles in lipid metabolism, cell cycling, and cancer progression. Our previous findings in AKI indicated a new role for AZGP1 in the regulation of fibrosis, which is a unifying feature of CKD. Using two models of chronic kidney injury, we now show that mice with genetic AZGP1 deletion develop significantly...

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PMID: 25788525
DOI: 10.1681/asn.2014050485

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