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Article

Reappraisal of profibrotic phenotype and cell-cycle state of renal tubular epithelium after ischemia-reperfusion injury.

PloS one - 1 Jan 2026

Fukaya Daichi, Kosakai Wakako, Sato Tetsuya, Inoue Tsutomu, Amano Hiroaki, Kusano Takeru, Okada Hirokazu

Abstract excerpt

Chronic kidney disease progression involves phenotypic changes in tubular epithelial cells, and recent studies have highlighted the relationship between such pro-fibrotic phenotypes and cell cycle arrest in injured tubular epithelial cells undergoing repair. We investigated these processes using a mouse unilateral ischemia-reperfusion injury model with γGT.Fucci2aR mice, which express fluorescent cell cycle...

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Identifiers

PMID: 42030280
DOI: 10.1371/journal.pone.0347835
PMCID: PMC13108746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 11 Sept 2026.

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