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FOXM1 drives proximal tubule proliferation during repair from acute ischemic kidney injury

10 Nov 2019

Abstract excerpt

The proximal tubule has a remarkable capacity for repair after acute injury, but the cellular lineage and molecular mechanisms underlying this repair response are incompletely understood. Here, we developed a Kim1-GFPCreERt2 knockin mouse line (Kim1-GCE) in order to perform genetic lineage tracing of dedifferentiated cells while measuring the cellular transcriptome of proximal tubule during repair. Acutely...

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PMID: 31710314
DOI: 10.1172/jci125519

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