Article
Aging phenotype(s) in kidneys of diabetic mice are p66ShcA dependent.
American journal of physiology. Renal physiology - 1 Dec 2018
Vashistha H, Marrero L, Reiss K, Cohen A J, Malhotra A, Javed T, Bradley A, Abbruscato F, Giusti S, Jimenez A, Mehra S, Kaushal D, Giorgio M, Pelicci P G, Kakoki M, Singhal P C, Bunnell B, Meggs L G
Abstract excerpt
The p66ShcA protein controls cellular responses to oxidative stress, senescence, and apoptosis. Here, we test the hypothesis that aging phenotype(s) commonly associated with the broad category of chronic kidney disease are accelerated in diabetic kidneys and linked to the p66ShcA locus. At the organ level, tissue stem cells antagonize senescent phenotypes by replacing old dysfunctional cells. Using established...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.