The secreted brain-derived neurotrophic factor precursor pro-BDNF binds to TrkB and p75NTR but not to TrkA or TrkC.

doi:10.1002/jnr.20432

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Article

The secreted brain-derived neurotrophic factor precursor pro-BDNF binds to TrkB and p75NTR but not to TrkA or TrkC.

Journal of neuroscience research - 1 Apr 2005

Fayard B, Loeffler S, Weis J, Vögelin E, Krüttgen A

Abstract excerpt

The neurotrophin brain-derived neurotrophic factor (BDNF) binds to two cell surface receptors: TrkB receptors that promote neuronal survival and differentiation and p75NTR that induces apoptosis or survival. BDNF, as well as the other members of the neurotrophin family, is synthesized as a larger precursor, pro-BDNF, which undergoes posttranslational modifications and proteolytic processing by furin or related...

Topics

Animals
Blotting, Western
Brain-Derived Neurotrophic Factor
COS Cells
Chlorocebus aethiops
Humans
Mutagenesis, Site-Directed
Mutation
PC12 Cells
Protein Precursors
Rats
Receptor, Nerve Growth Factor
Receptor, trkA
Receptor, trkB
Receptor, trkC
Receptors, Nerve Growth Factor

Source

Open in PubMed

Identifiers

PMID: 15704182
DOI: 10.1002/jnr.20432

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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