Article
The C242T polymorphism of the NAD(P)H oxidase p22phox subunit is associated with an enhanced risk for cerebrovascular disease at a young age.
Cerebrovascular diseases (Basel, Switzerland) - 1 Jan 2008
Genius Just, Grau Armin J, Lichy Christoph
Abstract excerpt
BACKGROUND AND PURPOSE: Oxidative stress has been proposed as a major contributing factor for vascular disease, that acts independently from its participation in predisposing disorders such as diabetes and arterial hypertension. A functionally relevant C242T polymorphism of the CYBA gene encoding the NAD(P)H oxidase p22(phox) subunit, is supposed to lead to an abnormal reduction in the generation of reactive...
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