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Article

C242T polymorphism of NADPH oxidase p22 PHOX gene and ischemic cerebrovascular disease in the Japanese population.

Stroke - 1 Apr 2000

Ito D, Murata M, Watanabe K, Yoshida T, Saito I, Tanahashi N, Fukuuchi Y

Abstract excerpt

BACKGROUND AND PURPOSE: Superoxide has been implicated in the pathogenesis of ischemic stroke and atherosclerosis. NADPH oxidase, a major source of superoxide generation in neutrophils and the vascular system, plays a critical role in ischemic injury and atherogenesis. Recently, an association between the C242T polymorphism of p22 PHOX, an essential component of NADPH oxidase, and coronary artery disease (CAD)...

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Source

Identifiers

PMID: 10754002
DOI: 10.1161/01.str.31.4.936

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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C242T polymorphism of NADPH oxidase p22 PHOX gene and ischemic cerebrovascular disease in the Japanese population.PMID 10754002Read ↗

Association between NADPH oxidase p22(phox) C242T polymorphism and ischemic cerebrovascular disease: a meta-analysis.Semantic proximity Read ↗

Functional effects of NAD(P)H oxidase p22(phox) C242T mutation in human leukocytes and association with thrombotic cerebral infarction.Semantic proximity Read ↗

Polymorphism of the NADH/NADPH Oxidase <i>p22 phox</i> Gene in Patients With Coronary Artery DiseaseSemantic proximity Read ↗

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The p22phox C242T gene polymorphism is associated with a reduced risk of angiographically verified coronary artery disease in a high-risk Finnish Caucasian population. The Finnish Cardiovascular Study.Semantic proximity Read ↗

Association between the C242T polymorphism of p22phox gene and ischemic stroke: a meta-analysis.Semantic proximity Read ↗

C242T polymorphism of NADPH oxidase p22phox gene reduces the risk of coronary artery disease in a random sample of Egyptian population.Semantic proximity Read ↗

NADH/NADPH oxidase <i>p22</i><i>phox</i> C242T polymorphism and coronary artery disease in the Australian populationSemantic proximity Read ↗

The C242T polymorphism of the NAD(P)H oxidase p22phox subunit is associated with an enhanced risk for cerebrovascular disease at a young age.Semantic proximity Read ↗

The p22 phox polymorphism C242T is not associated with CHD risk in Asian Indians and Chinese.Semantic proximity Read ↗

The C242T polymorphism of the p22phox component of NAD(P)H oxidase and vascular risk. Two case-control studies and a meta-analysis.Semantic proximity Read ↗

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