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The C242T polymorphism of the p22phox component of NAD(P)H oxidase and vascular risk. Two case-control studies and a meta-analysis.

Thrombosis and haemostasis - 1 Mar 2008

Di Castelnuovo Augusto, Soccio Manola, Iacoviello Licia, Evangelista Virgilio, Consoli Agostino, Vanuzzo Diego, Diviacco Silvia, Carluccio Marisa, Rignanese Lucia, De Caterina Raffaele

Abstract excerpt

NAD(P)H oxidase is a prominent source of reactive oxygen species in the vasculature. Vascular NAD(P)H oxidase is comprised of several subunits, one of which, p22phox, is encoded by a gene exhibiting several allelic variants. Here the C(242)T nucleotide transition has been found to alter superoxide anion production and associated with an altered risk of coronary artery disease (CAD). We assessed the role of this...

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PMID: 18327409
DOI: 10.1160/TH07-08-0480

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CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The C242T polymorphism of the p22phox component of NAD(P)H oxidase and vascular risk. Two case-control studies and a meta-analysis.PMID 18327409Read ↗

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