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Article

The C242T CYBA polymorphism of NADPH oxidase is associated with essential hypertension.

Journal of hypertension - 1 Jul 2006

Moreno María U, San José Gorka, Fortuño Ana, Beloqui Oscar, Díez Javier, Zalba Guillermo

Abstract excerpt

OBJECTIVE: Oxidative stress is implicated in hypertension. The reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidases are the main source of superoxide in phagocytic and vascular cells. The C242T polymorphism of CYBA, the human gene that encodes p22phox, has been found to be functionally associated with vascular NADPH oxidase activity in atherosclerotic patients. We investigated the association of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16794479
DOI: 10.1097/01.hjh.0000234110.54110.56

Genes

CYBA

Provenance

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The C242T CYBA polymorphism of NADPH oxidase is associated with essential hypertension.PMID 16794479Read ↗

A novel CYBA variant, the -675A/T polymorphism, is associated with essential hypertension.Semantic proximity Read ↗

The C242T CYBA polymorphism as a major determinant of NADPH oxidase activity in patients with cardiovascular disease.Semantic proximity Read ↗

C242T CYBA polymorphism of the NADPH oxidase is associated with reduced respiratory burst in human neutrophils.Semantic proximity Read ↗

Functional effect of the p22phox -930A/G polymorphism on p22phox expression and NADPH oxidase activity in hypertension.Semantic proximity Read ↗

The A640G CYBA polymorphism associates with subclinical atherosclerosis in diabetes.Semantic proximity Read ↗

The C242T p22phox polymorphism and endothelium-dependent vasodilation in subjects with hypercholesterolaemia.Semantic proximity Read ↗

NAD(P)H oxidase p22phox Gene C242T polymorphism and lipoprotein oxidation.Semantic proximity Read ↗

CYBA C242T gene polymorphism and flow-mediated vasodilation in a population of young adults: the Cardiovascular Risk in Young Finns Study.Semantic proximity Read ↗

CYBA (p22phox) variants associate with blood pressure and oxidative stress markers in hypertension: a replication study in populations of diverse altitudes.Semantic proximity Read ↗

C242T polymorphism of the NADPH oxidase p22PHOX gene and its association with endothelial dysfunction in asymptomatic individuals with essential systemic hypertension.Semantic proximity Read ↗

Effect of the CYBA C242T Polymorphism on Preeclampsia Pathogenesis in the Chinese Population.Semantic proximity Read ↗

The 242T variant of the CYBA gene polymorphism increases the risk of coronary artery disease associated with cigarette smoking and hypercholesterolemia.Semantic proximity Read ↗

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